PAW Hepatoadvanced Medium & Large Dog >15kg (30 tablets)

PAW Hepatoadvanced For Medium And Large Dogs Promotes Liver Detoxification. A concentrated antioxidant supplement to help manage compromised biomarkers of the liver. It is recommended that a veterinarians opinion be sought before and during the use of this product in order to determine the needs of your pet

Key Benefits

• Contains a stable form of S-adenosyl-L-methionine (SAMe) – central to the transmethylation, transsulfuration & aminopropylation pathways. Modulates cytokine expression, diminishes cholestasis, and regulates apoptosis
• Contains silybin – in a phospholipid complex – provides increased bioavailability compared to standard milk thistle, increases biliary flow, inhibits leukotriene production, modifies membrane function (inhibits toxin binding), restores expression and activity of antioxidant enzymes
• Contains vitamin E – promotes cell proliferation, modulates gene expression, and regulates cell signalling pathways that rely on reactive oxygen intermediates

Key Features

• Supports glutathione production
• Promotes detoxification of the liver 
• Helps to decrease the negative side effects of some medications on the liver
• Supports the liver in cases of acute liver toxicity
• Promotes proper brain function in dogs  
• Presented as a tasty, chewable tablet
• Simple and convenient dosing
• Formulated with delayed release technology – promotes steady metabolism by the liver and a prolonged duration of activity

If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced

Ingredients & Analysis

S-Adenosyl-L-methionine disulfate p-toluenesulfonate (equivalent to SAMe), D-alpha tocopherol succinate (Vitamin E), Silybin phospholipids (equivalent to silybin A+B), flavour, tablet diluents, binders and lubricants 

Hepatoadvanced may be used as an adjunctive therapy in conditions such as:

• Chronic hepatitis
• Hepatic lipidosis
• Cholangiohepatitis
• Paracetamol toxicity
• Hepatotoxic mushroom ingestion
• Copper related hepatopathy
• Iron overload - Medication use including NSAIDs, phenobarbital and corticosteroids (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• Metabolic hepatopathies
• Other acute or chronic hepatopathies
• Neoplasia
• Canine cognitive dysfunction
• Cirrhosis

Product Guide

• Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
• Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
• Safe use in pregnant or lactating animals has not been established
• For dogs under 15kg, use PAW Hepatoadvanced Cat & Small Dog

Typical Analysis

• DO NOT exceed 2 chewable tablets per day
• If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
• For optimal absorption, administer Hepatoadvanced (as per the dosing chart), once a day on an empty stomach
• Tablet may be broken in half but do not crush
• The recommended total daily dose for dogs and cats: S-adenosyl-L-methionine (sAMe): 10- 20mg/kg, SPC 2.7- 5.4mg/kg and vitamin E 10-15IU/kg
• Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
• The duration of treatment should be advised by your veterinarian 
• Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome

Dog Weight & Daily Dose

Safety Directions

• For animal use only
• For veterinary supply only
• Use with caution in pregnant or lactating animals as safe use has not been established

Side Effects of the Active Ingredients

SAMe

• SAMe has a wide safety margin
• Side effects or overdose effects are rare, but are limited to mild gastrointestinal signs, immediate post pill nausea and food refusal
• Concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), other antidepressants (amitriptyline, clomipramine) may theoretically cause additive serotonergic effects
• Use with caution simultaneously

Silymarin

• Silymarin typically has no side effects, but consider drug interactions in polymedicated patients, such as the following: antiviral drugs, drugs affected by cytochrome P450 & CYP3A4 inhibition and drugs cleared via hepatic glucuronidation

Vitamin E

• There are no commonly noted toxic effects derived from vitamin E supplementation, although it may inhibit the absorption of other fat- soluble vitamins when administered at high doses
• Therefore, it is recommended to not exceed a total daily dose of 400IU per dog
• Vitamin E is not recommended in liver disease patients with evidence of vitamin K deficiency