PAW Hepatoadvanced For Cat And Small Dogs Promotes Liver Detoxification. A concentrated antioxidant supplement to help manage compromised biomarkers of the liver. It is recommended that a veterinarians opinion be sought before and during the use of this product in order to determine the needs of your pet.
Key Benefits
- Contains a stable form of S-adenosyl-L-methionine (SAMe) – central to the transmethylation, transsulfuration & aminopropylation pathways. Modulates cytokine expression, diminishes cholestasis, and regulates apoptosis
- Contains silybin – in a phospholipid complex – provides increased bioavailability compared to standard milk thistle, increases biliary flow, inhibits leukotriene production, modifies membrane function (inhibits toxin binding), restores expression and activity of antioxidant enzymes
- Contains vitamin E – promotes cell proliferation, modulates gene expression, and regulates cell signalling pathways that rely on reactive oxygen intermediates
Key Features
- Supports glutathione production
- Promotes detoxification of the liver
- Helps to decrease the negative side effects of some medications on the liver
- Supports the liver in cases of acute liver toxicity
- Promotes proper brain function in dogs
- Presented as a tasty, chewable tablet
- Simple and convenient dosing
- Formulated with delayed release technology – promotes steady metabolism by the liver and a prolonged duration of activity
If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
Ingredients & Analysis
S-Adenosyl-L-methionine disulfate p-toluenesulfonate (equivalent to SAMe), D-alpha tocopherol succinate (Vitamin E), Silybin phospholipids (equivalent to silybin A+B), flavour, tablet diluents, binders and lubricants
| Active Ingredients | Cat and Small Dog (under 15kg) |
| (S) S-Adenosyl-L-methionine disulfate p-toluenesulfonate (Equivalent to SAMe) | 50 mg |
| D-alpha tocopherol succinate (Vitamin E) | 45 IU |
| Silybin Phospholipids (Equivalent to silybin A+B) | 13 mg |
Hepatoadvanced may be used as an adjunctive therapy in conditions such as:
- Chronic hepatitis
- Hepatic lipidosis
- Cholangiohepatitis
- Paracetamol toxicity
- Hepatotoxic mushroom ingestion
- Copper related hepatopathy
- Iron overload - Medication use including NSAIDs, phenobarbital and corticosteroids (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
- Metabolic hepatopathies
- Other acute or chronic hepatopathies
- Neoplasia
- Canine cognitive dysfunction
- Cirrhosis
Product Guide
- Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
- Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
- Safe use in pregnant or lactating animals has not been established
Typical Analysis
- DO NOT exceed 2 chewable tablets per day
- If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
- For optimal absorption, administer Hepatoadvanced (as per the dosing chart), once a day on an empty stomach
- Tablet may be broken in half but do not crush
- The recommended total daily dose for dogs and cats: S-adenosyl-L-methionine (sAMe): 10- 20mg/kg, SPC 2.7- 5.4mg/kg and vitamin E 10-15IU/kg
- Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
- The duration of treatment should be advised by your veterinarian
- Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
Dog Weight & Daily Dose
| Weight Range |
Dosage per day
|
| 1 – 2.4 kg | 1 tablet |
| 2.5 – 9.9 kg | 2 tablets |
| 10 – 14.9 kg | 3 tablets |
Safety Directions
- For animal use only
- For veterinary supply only
- Use with caution in pregnant or lactating animals as safe use has not been established
Side Effects of the Active Ingredients
SAMe
- SAMe has a wide safety margin
- Side effects or overdose effects are rare, but are limited to mild gastrointestinal signs, immediate post pill nausea and food refusal
- Concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), other antidepressants (amitriptyline, clomipramine) may theoretically cause additive serotonergic effects
- Use with caution simultaneously
Silymarin
- Silymarin typically has no side effects, but consider drug interactions in polymedicated patients, such as the following: antiviral drugs, drugs affected by cytochrome P450 & CYP3A4 inhibition and drugs cleared via hepatic glucuronidation
Vitamin E
- There are no commonly noted toxic effects derived from vitamin E supplementation, although it may inhibit the absorption of other fat- soluble vitamins when administered at high doses
- Therefore, it is recommended to not exceed a total daily dose of 400IU per dog
- Vitamin E is not recommended in liver disease patients with evidence of vitamin K deficiency
25 Reviews Hide Reviews Show Reviews
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This product has helped my Jack Russell's liver settle down
Blood tests before and after taking this medication showed improvement. He's doing a lot better on it.
Only negative is that the tablets are large and not really chewable. They are more like a large tablet trxture than a chew. I do have trouble getting my jack russel to take it. -
Hepatadvanced
My dog needs these tablets daily, thankfully Pet Chemist are the best price available. Very impressed also with the delivery of products.
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Paw hepatoadvanced
Excellent product at besr price
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Hepatoadvanced small cat and dog
This is the 1st time I have used these tablets given they are the only tablets available by way of being permanent replacement meds for Denosyl and Denamarin. I can say I am happy that these meds per tablet can be halved for my dogs daily dosage and thus resulting in a full box will.last me twice as long as the previous brands mentioned above. My dog has not noticed any difference and is happy to eat them as per usual so that's a 5☆ in itself.
Thankyou for this opportunity to give my feedback.
Cheers -
good product
I needed to give to my dog doing chemotherapy to protect his liver from the drug. His next bloodwork showed normal level of liver enzymes so I guess it is working. Very expensive but got my vet to sign a prescription to buy online which was half the price. Will need to take it for couple of months so ordered auto ship to make it more cheaper.
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hepatoadvanced
medication prescribed by vet. Price is very good and service is excellent will be buying this again as my dog has to be on it for the rest of his life.
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It's a big tablet, for a small dog.
I had been told that it would be cheaper if I had a prescription, but you told me it was an over-the-counter product. very expensive for a retiree.
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Hepatodvanced
This medication is vital for my elderly dog (Goldie) quality of life. This has definitely prolonged his life expectancy. Fantastic!
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Heptoadvanced
OMG terrible, this tablet has a horrible horrible taste, smell and texture. My dog will NOT eat it not matter what I hide it in. It is NOT a chewable table, and it is so dry and scratchy. I have to force it down my dogs throat and it hard for my nearly 16 year only dog to swallow because of its texture. This product is a total failure by Blackmores. Blackmores previous version of this medicine Denosyl was a far superior product.
