PAW Hepatoadvanced For Cat And Small Dogs Promotes Liver Detoxification. A concentrated antioxidant supplement to help manage compromised biomarkers of the liver. It is recommended that a veterinarians opinion be sought before and during the use of this product in order to determine the needs of your pet.
Key Benefits
- Contains a stable form of S-adenosyl-L-methionine (SAMe) – central to the transmethylation, transsulfuration & aminopropylation pathways. Modulates cytokine expression, diminishes cholestasis, and regulates apoptosis
- Contains silybin – in a phospholipid complex – provides increased bioavailability compared to standard milk thistle, increases biliary flow, inhibits leukotriene production, modifies membrane function (inhibits toxin binding), restores expression and activity of antioxidant enzymes
- Contains vitamin E – promotes cell proliferation, modulates gene expression, and regulates cell signalling pathways that rely on reactive oxygen intermediates
Key Features
- Supports glutathione production
- Promotes detoxification of the liver
- Helps to decrease the negative side effects of some medications on the liver
- Supports the liver in cases of acute liver toxicity
- Promotes proper brain function in dogs
- Presented as a tasty, chewable tablet
- Simple and convenient dosing
- Formulated with delayed release technology – promotes steady metabolism by the liver and a prolonged duration of activity
If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
Ingredients & Analysis
S-Adenosyl-L-methionine disulfate p-toluenesulfonate (equivalent to SAMe), D-alpha tocopherol succinate (Vitamin E), Silybin phospholipids (equivalent to silybin A+B), flavour, tablet diluents, binders and lubricants
Active Ingredients | Cat and Small Dog (under 15kg) |
(S) S-Adenosyl-L-methionine disulfate p-toluenesulfonate (Equivalent to SAMe) | 50 mg |
D-alpha tocopherol succinate (Vitamin E) | 45 IU |
Silybin Phospholipids (Equivalent to silybin A+B) | 13 mg |
Hepatoadvanced may be used as an adjunctive therapy in conditions such as:
- Chronic hepatitis
- Hepatic lipidosis
- Cholangiohepatitis
- Paracetamol toxicity
- Hepatotoxic mushroom ingestion
- Copper related hepatopathy
- Iron overload - Medication use including NSAIDs, phenobarbital and corticosteroids (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
- Metabolic hepatopathies
- Other acute or chronic hepatopathies
- Neoplasia
- Canine cognitive dysfunction
- Cirrhosis
Product Guide
- Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
- Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
- Safe use in pregnant or lactating animals has not been established
Typical Analysis
- DO NOT exceed 2 chewable tablets per day
- If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
- For optimal absorption, administer Hepatoadvanced (as per the dosing chart), once a day on an empty stomach
- Tablet may be broken in half but do not crush
- The recommended total daily dose for dogs and cats: S-adenosyl-L-methionine (sAMe): 10- 20mg/kg, SPC 2.7- 5.4mg/kg and vitamin E 10-15IU/kg
- Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
- The duration of treatment should be advised by your veterinarian
- Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
Dog Weight & Daily Dose
Weight Range |
Dosage per day
|
1 – 2.4 kg | 1 tablet |
2.5 – 9.9 kg | 2 tablets |
10 – 14.9 kg | 3 tablets |
Safety Directions
- For animal use only
- For veterinary supply only
- Use with caution in pregnant or lactating animals as safe use has not been established
Side Effects of the Active Ingredients
SAMe
- SAMe has a wide safety margin
- Side effects or overdose effects are rare, but are limited to mild gastrointestinal signs, immediate post pill nausea and food refusal
- Concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), other antidepressants (amitriptyline, clomipramine) may theoretically cause additive serotonergic effects
- Use with caution simultaneously
Silymarin
- Silymarin typically has no side effects, but consider drug interactions in polymedicated patients, such as the following: antiviral drugs, drugs affected by cytochrome P450 & CYP3A4 inhibition and drugs cleared via hepatic glucuronidation
Vitamin E
- There are no commonly noted toxic effects derived from vitamin E supplementation, although it may inhibit the absorption of other fat- soluble vitamins when administered at high doses
- Therefore, it is recommended to not exceed a total daily dose of 400IU per dog
- Vitamin E is not recommended in liver disease patients with evidence of vitamin K deficiency
25 Reviews Hide Reviews Show Reviews
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Very good product my dog has been a lot better.
Much better than the previous denamarin
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hepatoadvanced
as prescribed by vet. very good service and price.
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Great value
I cannot believe how good the price of this product is and availability with the prompt delivery. I would recommend purchasing g from this company.
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Hepatodvanced
This product has given my 13 yr old foxie a new lease of life. He has got his energy back and certainly his appetite.
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Blackmores Hepatoadvanced
Slightly harder to get my dog to swallow than the denamarin/denosyl, but as I only need to give my dog half a tablet, this type lasts twice as long and works out cheaper.
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Better product than the old Denamarin
Excellent serv
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HepatoAdvanced
Great service and being new product much cheaper than well known online pet food supplier. Delivered on time per expected delivery quoted.