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PAW Hepatoadvanced Cat & Small Dog <15kg (60 tablets)

(25 reviews) Write a Review
SKU:
PH-PAW41566
UPC:
9300807351628

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“Post original prescription to: PO Box 999, Tweed Heads, NSW 2485”


PAW Hepatoadvanced For Cat And Small Dogs Promotes Liver Detoxification. A concentrated antioxidant supplement to help manage compromised biomarkers of the liver. It is recommended that a veterinarians opinion be sought before and during the use of this product in order to determine the needs of your pet.

Key Benefits

  • Contains a stable form of S-adenosyl-L-methionine (SAMe) – central to the transmethylation, transsulfuration & aminopropylation pathways. Modulates cytokine expression, diminishes cholestasis, and regulates apoptosis
  • Contains silybin – in a phospholipid complex – provides increased bioavailability compared to standard milk thistle, increases biliary flow, inhibits leukotriene production, modifies membrane function (inhibits toxin binding), restores expression and activity of antioxidant enzymes
  • Contains vitamin E – promotes cell proliferation, modulates gene expression, and regulates cell signalling pathways that rely on reactive oxygen intermediates

Key Features

  • Supports glutathione production
  • Promotes detoxification of the liver
  • Helps to decrease the negative side effects of some medications on the liver
  • Supports the liver in cases of acute liver toxicity
  • Promotes proper brain function in dogs
  • Presented as a tasty, chewable tablet
  • Simple and convenient dosing
  • Formulated with delayed release technology – promotes steady metabolism by the liver and a prolonged duration of activity

If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced

Ingredients & Analysis

S-Adenosyl-L-methionine disulfate p-toluenesulfonate (equivalent to SAMe), D-alpha tocopherol succinate (Vitamin E), Silybin phospholipids (equivalent to silybin A+B), flavour, tablet diluents, binders and lubricants 

Active Ingredients Cat and Small Dog (under 15kg)
(S) S-Adenosyl-L-methionine disulfate p-toluenesulfonate (Equivalent to SAMe) 50 mg
D-alpha tocopherol succinate (Vitamin E) 45 IU
Silybin Phospholipids (Equivalent to silybin A+B) 13 mg

Hepatoadvanced may be used as an adjunctive therapy in conditions such as:

  • Chronic hepatitis
  • Hepatic lipidosis
  • Cholangiohepatitis
  • Paracetamol toxicity
  • Hepatotoxic mushroom ingestion
  • Copper related hepatopathy
  • Iron overload - Medication use including NSAIDs, phenobarbital and corticosteroids (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
  • Metabolic hepatopathies
  • Other acute or chronic hepatopathies
  • Neoplasia
  • Canine cognitive dysfunction
  • Cirrhosis

Product Guide

  • Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
  • Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
  • Safe use in pregnant or lactating animals has not been established

Typical Analysis

  • DO NOT exceed 2 chewable tablets per day
  • If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
  • For optimal absorption, administer Hepatoadvanced (as per the dosing chart), once a day on an empty stomach
  • Tablet may be broken in half but do not crush
  • The recommended total daily dose for dogs and cats: S-adenosyl-L-methionine (sAMe): 10- 20mg/kg, SPC 2.7- 5.4mg/kg and vitamin E 10-15IU/kg
  • Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
  • The duration of treatment should be advised by your veterinarian 
  • Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome

Dog Weight & Daily Dose

Weight Range
Dosage per day
1 – 2.4 kg 1 tablet
2.5 – 9.9 kg 2 tablets
10 – 14.9 kg 3 tablets

Safety Directions

  • For animal use only
  • For veterinary supply only
  • Use with caution in pregnant or lactating animals as safe use has not been established

Side Effects of the Active Ingredients

SAMe

  • SAMe has a wide safety margin
  • Side effects or overdose effects are rare, but are limited to mild gastrointestinal signs, immediate post pill nausea and food refusal
  • Concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), other antidepressants (amitriptyline, clomipramine) may theoretically cause additive serotonergic effects
  • Use with caution simultaneously

Silymarin

  • Silymarin typically has no side effects, but consider drug interactions in polymedicated patients, such as the following: antiviral drugs, drugs affected by cytochrome P450 & CYP3A4 inhibition and drugs cleared via hepatic glucuronidation

Vitamin E

  • There are no commonly noted toxic effects derived from vitamin E supplementation, although it may inhibit the absorption of other fat- soluble vitamins when administered at high doses
  • Therefore, it is recommended to not exceed a total daily dose of 400IU per dog
  • Vitamin E is not recommended in liver disease patients with evidence of vitamin K deficiency
Liver Care
Dog
Cat

25 Reviews Hide Reviews Show Reviews

  • 5

    Very good product my dog has been a lot better.

    Posted by John LoRicco on 12th Sep 2022

    Much better than the previous denamarin

  • 5

    hepatoadvanced

    Posted by DIANE PERKINS on 9th Sep 2022

    as prescribed by vet. very good service and price.

  • 5

    Great value

    Posted by Alan G on 18th Aug 2022

    I cannot believe how good the price of this product is and availability with the prompt delivery. I would recommend purchasing g from this company.

  • 5

    Hepatodvanced

    Posted by Leanne Wilson on 12th Aug 2022

    This product has given my 13 yr old foxie a new lease of life. He has got his energy back and certainly his appetite.

  • 5

    Blackmores Hepatoadvanced

    Posted by Renee on 4th Aug 2022

    Slightly harder to get my dog to swallow than the denamarin/denosyl, but as I only need to give my dog half a tablet, this type lasts twice as long and works out cheaper.

  • 5

    Better product than the old Denamarin

    Posted by John LoRicco on 11th Jul 2022

    Excellent serv

  • 5

    HepatoAdvanced

    Posted by Alan Gordon on 9th Jul 2022

    Great service and being new product much cheaper than well known online pet food supplier. Delivered on time per expected delivery quoted.